Knoxville, Tennessee blends Southern hospitality, scenic mountain landscapes, and a growing cultural scene. Located near the Great Smoky Mountains, the area offers a mix of outdoor adventure and peaceful countryside retreats, along with a curated selection of boutique hotels and intimate stays that emphasize comfort, nature, and refined design.
To identify the best boutique hotels in Knoxville, TN, our editorial team evaluated guest reviews across major platforms, overall ratings, design and guest experience, and location appeal. The properties below stand out for their distinctive atmosphere and memorable stays.